Chapter 5 Filter ADAT

The filter tab is used for removing samples based on categorical or continuous columns.

5.1 Filter ADAT contents

Samples present in the ADAT file can be filtered based on Meta Data or SomaScan Assay data. When the ADAT file is processed, data columns are divided into Categorical (non-numeric) or Continuous (numeric) categories.

All filtering operations are cumulative.

The Filters box.

5.1.1 Categorical Filters

Samples can be filtered from the ADAT based on categorical data using the Filters box and selecting Categorical as the Filter Type. The column name can be selected from the Filter By selection box, which populates the Remove selection box with the unique categorical values in the ADAT file. Data values can be selected by clicking on one or more values in the Remove selection box. Once all selections are made, clicking the Apply button will remove those samples from the data, and the Data Dimensions box will be updated with new information.

In this example, the SampleType column is selected and the unique entries for this column are shown: Buffer, Calibrator, QC, and Sample. By clicking on Buffer, Calibrator, and QC, to select them, the assay control samples can be removed from the data file.

Checking the Filter samples with no entry box will remove all samples lacking a value for the selected column.

Example categorical filtering options

5.1.2 Continuous Filters

Samples can be filtered from the ADAT based on continuous data using the Filters box and selecting Continuous as the Filter Type. The column name can be selected from the Filter By which will update the Range slider with the minimum and maximum values for that data column. By moving the minimum and maximum sliders, a desired range of the selected variable can be chosen and all samples with values outside that range will be removed.

In this example, the Age column is selected and the sliders adjusted to keep only those samples with Age from 35 to 70.

Checking the Filter samples with no entry box will remove all samples lacking a value for the selected column.

Example continuous filtering options

5.1.3 Reset Filters

The original ADAT contents are always preserved and can be retrieved by clicking the Reset button.

5.1.4 Download ADAT

Once filtering has been performed, a version of the ADAT can be downloaded by clicking the Download ADAT button. The new ADAT will be downloaded as the original filename with “_modified.adat” appended Keeping good notes regarding the filtering operations is essential to recall how the ADAT was modified when it is returned to at a later date. To assist in this record keeping, an additional entry is made in the ^HEADER section of the ADAT file listing the operations that were performed.

SomaLogic, SomaScan, SOMAmer and associated logo are trademarks owned by SomaLogic Operating Company, Inc.